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D, Thomas (2018), America on Steroids: A Time to Heal. The direct effect is due to its ability to facilitate cellular uptake of glucose and the building blocks of protein (amino acids) from the blood. The clinical use of prednisone started around 1955, and it has literally saved thousands of lives since that time. Anabolic steroids cause hypertension that likely contributes to the most commonly associated cardiac morphologic abnormality, namely, hypertrophy.

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